Finite states in four dimensional quantum gravity. The isotropic minisuperspace Asktekar--Klein--Gordon model

In this paper we construct the generalized Kodama state for the case of a Klein--Gordon scalar field coupled to Ashtekar variables in isotropic minisuperspace by a new method. The criterion for finiteness of the state stems from a minisuperspace reduction of the quantized full theory, rather than the conventional techniques of reduction prior to quantization. We then provide a possible route to the reproduction of a semiclassical limit via these states. This is the result of a new principle of the semiclassical-quantum correspondence (SQC), introduced in the first paper in this series. Lastly, we examine the solution to the minisuperspace case at the semiclassical level for an isotropic CDJ matrix neglecting any quantum corrections and examine some of the implications in relation to results from previous authors on semiclassical orbits of spacetime, including inflation. It is suggested that the application of nonperturbative quantum gravity, by way of the SQC, might potentially lead to some predictions testable below the Planck scale.Comment: 26 pages. Accepted for publication by Class. Quantum Grav. journa

Herbicidan control of water hyacinth at Ere, Ogun State: implications for fish production

A brief account is given of a pilot demonstration of the chemical control of water hyacinth (Eichhornia crassipes) at Ere (a channel) in Nigeria using the herbicide glyphosphate. Results suggest that there was an increase in the nutrient content of the channel after herbicide application. This implied an upsurge of available food for fish and other aquatic organisms within the channel after the herbicide application. The decaying water hyacinth mass which sinks into the medium is likely to boost nutrient content, promoting the growth of fish and other aquatic animals. It is concluded that herbicidal control of water hyacinth is possible, especially under specialists' management with the conservation of fish and other non-target aquatic organisms alongside improved fish productio

Sonographic Correlation of Liver Dimension and Anthropometric Variables of Height, Weight and Body Mass Index (BMI)

Background: Estimation of liver size can be used as an index to monitor various aspects of liver disease and response to therapy.Purpose: To evaluate the relationship between anthropometric variables (Height, Weight and Body Mass Index) with liver size was carried out in subjects with clinically and sonographically confirmed normal liver.Materials & Methods: This prospective sonographic study was carried out in Calabar, Uyo, Zaria and Makurdicosmopolitan cities of Nigeria. Scans were performed on 388 subjects and their liver sizes measured in the Midclavicular and anterior axillary lines, respectively. Patients’ heights and weights were also measured and used to calculate their respective body mass indices.Results: Mean liver diameter in the study population was 12.9±1.7cm (Range 9.2 – 15.2cm) and 11.6±1.7cm (Range 8.0 – 14.5cm) at the midclavicular and anterior axillary lines respectively. About 98.5 % of the study population had liver sizes ≤15.0cm while 1.5% had sizes at the upper limits of 15.3 – 16cm. Height and BMI appeared to have sone influence on liver size (r=+60; P<0.05, +0.65; P<0.05) respectively at the midclavicular line but not at the anterior axillary line. An insignificant relationship was observed with weight and liver size (r= +0.1; P<0.05) both in the MCL and AAL.Conclusion: Liver size is affected more by individual’s height and body mass index and less by their weight in the region studied

Design and construction of a Cherenkov imager for charge measurement of nuclear cosmic rays

A proximity focusing Cherenkov imager called CHERCAM, has been built for the charge measurement of nuclear cosmic rays with the CREAM instrument. It consists of a silica aerogel radiator plane across from a detector plane equipped with 1,600 1" diameter photomultipliers. The two planes are separated by a ring expansion gap. The Cherenkov light yield is proportional to the charge squared of the incident particle. The expected relative light collection accuracy is in the few percents range. It leads to an expected single element separation over the range of nuclear charge Z of main interest 1 < Z < 26. CHERCAM is designed to fly with the CREAM balloon experiment. The design of the instrument and the implemented technical solutions allowing its safe operation in high altitude conditions (radiations, low pressure, cold) are presented.Comment: 24 pages, 19 figure

First report of Theileria annulata in Nigeria : findings from cattle ticks in Zamfara and Sokoto States

Background: Ticks and tick-borne pathogens (TBPs) represent a significant economic burden to cattle farming in sub-Saharan Africa including Nigeria. However, in the northern part of this country, where the largest livestock population resides, little is known about the contemporary diversity of ticks and TBPs. This area is particularly vulnerable to climate change, undergoing marked transformation of habitat and associated flora and fauna that is also likely to include ticks. This study aimed to document the occurrence of tick species and Apicomplexan TBPs in cattle from north-western Nigeria. Methods: In 2017, ticks were collected from cattle in Zamfara and Sokoto States and identified morphologically. Additionally, a subset of ticks was screened molecularly for the detection of apicomplexan DNA. Results: A total of 494 adult ticks were collected from 80 cattle in Zamfara and 65 cattle in Sokoto State. Nine tick species were encountered, among which the presence of one, Hyalomma turanicum, had not previously been recorded in Nigeria. Hyalomma rufipes was the most prevalent tick infesting cattle in Zamfara State (76%), while Hyalomma dromedarii was the most prevalent in Sokoto State (44%), confirming the widespread transfer of this species from camels onto livestock and its adaptation to cattle in the region. Of 159 ticks screened, 2 out of 54 (3.7%) from Zamfara State and 29 out of 105 (27.6%) from Sokoto State harboured DNA of Theileria annulata, the agent of tropical theileriosis. Conclusions: This study confirms the presence of a broad diversity of tick species in cattle from north-western Nigeria, providing the first locality records for Zamfara State. The occurrence of H. turanicum indicates a distribution of this tick beyond northern Africa. This study provides the first report for T. annulata in Nigerian ticks. Given its enormous burden on livestock farming in north Africa and across Asia, further investigations are needed to better understand its epidemiology, vector transmission and potential clinical significance in cattle from northern Nigeria and neighbouring Sahelian countries

Neuronal hyperactivity disturbs ATP microgradients, impairs microglial motility, and reduces phagocytic receptor expression triggering apoptosis/microglial phagocytosis uncoupling

Phagocytosis is essential to maintain tissue homeostasis in a large number of inflammatory and autoimmune diseases, but its role in the diseased brain is poorly explored. Recent findings suggest that in the adult hippocampal neurogenic niche, where the excess of newborn cells undergo apoptosis in physiological conditions, phagocytosis is efficiently executed by surveillant, ramified microglia. To test whether microglia are efficient phagocytes in the diseased brain as well, we confronted them with a series of apoptotic challenges and discovered a generalized response. When challenged with excitotoxicity in vitro (via the glutamate agonist NMDA) or inflammation in vivo (via systemic administration of bacterial lipopolysaccharides or by omega 3 fatty acid deficient diets), microglia resorted to different strategies to boost their phagocytic efficiency and compensate for the increased number of apoptotic cells, thus maintaining phagocytosis and apoptosis tightly coupled. Unexpectedly, this coupling was chronically lost in a mouse model of mesial temporal lobe epilepsy (MTLE) as well as in hippocampal tissue resected from individuals with MTLE, a major neurological disorder characterized by seizures, excitotoxicity, and inflammation. Importantly, the loss of phagocytosis/apoptosis coupling correlated with the expression of microglial proinflammatory, epileptogenic cytokines, suggesting its contribution to the pathophysiology of epilepsy. The phagocytic blockade resulted from reduced microglial surveillance and apoptotic cell recognition receptor expression and was not directly mediated by signaling through microglial glutamate receptors. Instead, it was related to the disruption of local ATP microgradients caused by the hyperactivity of the hippocampal network, at least in the acute phase of epilepsy. Finally, the uncoupling led to an accumulation of apoptotic newborn cells in the neurogenic niche that was due not to decreased survival but to delayed cell clearance after seizures. These results demonstrate that the efficiency of microglial phagocytosis critically affects the dynamics of apoptosis and urge to routinely assess the microglial phagocytic efficiency in neurodegenerative disorders